منابع مشابه
Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation.
The UV-damaged DNA binding protein complex (UV-DDB) is implicated in global genomic nucleotide excision repair (NER) in mammalian cells. The complex consists of a heterodimer of p127 and p48. UV-DDB is defective in one complementation group (XP-E) of the heritable, skin cancer-prone disorder xeroderma pigmentosum. Upon UV irradiation of primate cells, UV-DDB associates tightly with chromatin, c...
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UV light-induced photoproducts are recognized and removed by the nucleotide-excision repair (NER) pathway. In humans, the UV-damaged DNA-binding protein (UV-DDB) is part of a ubiquitin E3 ligase complex (DDB1-CUL4A(DDB2)) that initiates NER by recognizing damaged chromatin with concomitant ubiquitination of core histones at the lesion. We report the X-ray crystal structure of the human UV-DDB i...
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UV absorbance measurements in microplates became possible only five years ago when Molecular Devices (Sunnyvale, CA, USA) introduced the SPECTRAmax 250, the first UV-Visible microplate spectrophotometer. Microplates have since become very popular for making UV measurements of DNA, RNA and protein concentrations because of their higher throughput compared to traditional cuvettes. Despite their ...
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In both natural and agricultural conditions, plants are frequently subjected to unfavourable environments, resulting in varying degrees of stress. UV irradiation, drought, heat shock, chilling/freezing, salinity and oxygen deficiency are a few of the major abiotic factors restricting plant growth and development. An important consequence of stratospheric ozone depletion is increased transmissio...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2017
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkx1185